Anti-SSB antibody (166-408) (STJ25701)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SSB (166-408) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:100-1:500IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your speci |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SSB |
| Gene ID | 6741 |
| Uniprot ID | LA_HUMAN |
| Immunogen Region | 166-408 |
| Immunogen Sequence | KFVETPGQKYKETDLLILFK DDYFAKKNEERKQNKVEAKL RAKQEQEAKQKLEEDAEMKS LEEKIGCLLKFSGDLDDQTC REDLHILFSNHGEIKWIDFV RGAKEGIILFKEKAKEALGK AKDANNGNLQLRNKEVTWEV LEGEVEKEALKKIIEDQQES LNKWKSKGRRFKGKGKGNKA AQPGSGKGKVQFQGKKTKFA SDDEHDEHDENGATGPVKRA REETDKEEPASKQQKTENG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 166-408 of human SSB (NP_003133.1). |
Additional Info
| Post Translational Modifications | Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. The N-terminus is blocked. |
| Function | Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. |
| Protein Name | Lupus La ProteinLa AutoantigenLa RibonucleoproteinSjoegren Syndrome Type B AntigenSs-B |
| Database Links | Reactome: R-HSA-73980Reactome: R-HSA-749476 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lupus La Protein antibodyAnti-La Autoantigen antibodyAnti-La Ribonucleoprotein antibodyAnti-Sjoegren Syndrome Type B Antigen antibodyAnti-Ss-B antibodyAnti-SSB antibody |
Information sourced from Uniprot.org