| Short Description : | Rabbit polyclonal SFRS9 (1-221) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRSF9 |
| Gene ID: | 8683 |
| Uniprot ID: | SRSF9_HUMAN |
| Immunogen Region: | 1-221 |
| Immunogen Sequence: | MSGWADERGGEGDGRIYVGN LPTDVREKDLEDLFYKYGRI REIELKNRHGLVPFAFVRFE DPRDAEDAIYGRNGYDYGQC RLRVEFPRTYGGRGGWPRGG RNGPPTRRSDFRVLVSGLPP SGSWQDLKDHMREAGDVCYA DVQKDGVGMVEYLRKEDMEY ALRKLDDTKFRSHEGETSYI RVYPERSTSYGYSRSRSGSR GRDSPYQSRGSPHYFSPFRP Y |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-221 of human SFRS9 (NP_003760.1). |
| Tissue Specificity | Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle. |
| Post Translational Modifications | Extensively phosphorylated on serine residues in the RS domain. |
| Function | Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 9Pre-Mrna-Splicing Factor Srp30cSplicing Factor - Arginine/Serine-Rich 9 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusCellular Stresses Such As Heat Shock May Induce Localization To Discrete Nuclear Bodies Termed Sam68 Nuclear Bodies (Snbs)Hap BodiesOr Stress BodiesNumerous Splicing Factors Including Srsf1/Sfrs1/Sf2Srsf7/Sfrs7Safb And Khdrbs1/Sam68 Accumulate At These StructuresWhich May Participate In The Post-Transcriptional Regulation Of Mrnas In Stressed Cells |
| Alternative Antibody Names | Anti-Serine/Arginine-Rich Splicing Factor 9 antibodyAnti-Pre-Mrna-Splicing Factor Srp30c antibodyAnti-Splicing Factor - Arginine/Serine-Rich 9 antibodyAnti-SRSF9 antibodyAnti-SFRS9 antibodyAnti-SRP30C antibody |
Information sourced from Uniprot.org
![Immunofluorescence analysis of HepG2 cells using [KD Validated] RAB27A Rabbit polyclonal antibody (STJ25258) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/100398/386820/STJ25258_1__87091.1713155968.jpg?c=1 "Immunofluorescence analysis of HepG2 cells using [KD Validated] RAB27A Rabbit polyclonal antibody (STJ25258) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
