| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRSF7 |
| Gene ID: | 6432 |
| Uniprot ID: | SRSF7_HUMAN |
| Immunogen Region: | 60-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-120 of human SRSF7 (NP_001026854). |
| Immunogen Sequence: | AEDAVRGLDGKVICGSRVRV ELSTGMPRRSRFDRPPARRP FDPNDRCYECGEKGHYAYDC H |
| Tissue Specificity | Brain, liver, kidney and lung. |
| Post Translational Modifications | Extensively phosphorylated on serine residues in the RS domain. |
| Function | Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway).enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 7Splicing Factor 9g8Splicing Factor - Arginine/Serine-Rich 7 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Serine/Arginine-Rich Splicing Factor 7 antibodyAnti-Splicing Factor 9g8 antibodyAnti-Splicing Factor - Arginine/Serine-Rich 7 antibodyAnti-SRSF7 antibodyAnti-SFRS7 antibody |
Information sourced from Uniprot.org