| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRRM1 |
| Gene ID: |
10250 |
| Uniprot ID: |
SRRM1_HUMAN |
| Immunogen Region: |
1-160 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRRM1 (NP_005830.2). |
| Immunogen Sequence: |
MDAGFFRGTSAEQDNRFSNK QKKLLKQLKFAECLEKKVDM SKVNLEVIKPWITKRVTEIL GFEDDVVIEFIFNQLEVKNP DSKMMQINLTGFLNGKNARE FMGELWPLLLSAQENIAGIP SAFLELKKEEIKQRQIEQEK LASMKKQDEDKDKRDKEEKE |
| Post Translational Modifications | Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown. Phosphorylation by DYRK3 promotes disassembly of nuclear speckles. Citrullinated by PADI4. |
| Function | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. |
| Protein Name | Serine/Arginine Repetitive Matrix Protein 1Sr-Related Nuclear Matrix Protein Of 160 KdaSrm160Ser/Arg-Related Nuclear Matrix Protein |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | Nucleus MatrixNucleus Speckle |
| Alternative Antibody Names | Anti-Serine/Arginine Repetitive Matrix Protein 1 antibodyAnti-Sr-Related Nuclear Matrix Protein Of 160 Kda antibodyAnti-Srm160 antibodyAnti-Ser/Arg-Related Nuclear Matrix Protein antibodyAnti-SRRM1 antibodyAnti-SRM160 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
