| Post Translational Modifications | Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown. Phosphorylation by DYRK3 promotes disassembly of nuclear speckles. Citrullinated by PADI4. |
| Function | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. |
| Protein Name | Serine/Arginine Repetitive Matrix Protein 1Sr-Related Nuclear Matrix Protein Of 160 KdaSrm160Ser/Arg-Related Nuclear Matrix Protein |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | Nucleus MatrixNucleus Speckle |
| Alternative Antibody Names | Anti-Serine/Arginine Repetitive Matrix Protein 1 antibodyAnti-Sr-Related Nuclear Matrix Protein Of 160 Kda antibodyAnti-Srm160 antibodyAnti-Ser/Arg-Related Nuclear Matrix Protein antibodyAnti-SRRM1 antibodyAnti-SRM160 antibody |
Information sourced from Uniprot.org
