| Tissue Specificity | Expressed in the cerebellum, hippocampus, dorsolateral prefrontal cortex, and in motor neurons and glial cells of the lumbar spinal cord (at protein level). Increased in the dorsolateral prefrontal cortex of schizophrenic patients (at protein level). Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney, and liver. |
| Post Translational Modifications | S-nitrosylated, leading to decrease the enzyme activity. |
| Function | Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. |
| Protein Name | Serine RacemaseD-Serine Ammonia-LyaseD-Serine DehydrataseL-Serine Ammonia-LyaseL-Serine Dehydratase |
| Database Links | Reactome: R-HSA-977347 |
| Alternative Antibody Names | Anti-Serine Racemase antibodyAnti-D-Serine Ammonia-Lyase antibodyAnti-D-Serine Dehydratase antibodyAnti-L-Serine Ammonia-Lyase antibodyAnti-L-Serine Dehydratase antibodyAnti-SRR antibody |
Information sourced from Uniprot.org
