| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRPRA |
| Gene ID: | 6734 |
| Uniprot ID: | SRPRA_HUMAN |
| Immunogen Region: | 1-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SRPR (NP_003130.2). |
| Immunogen Sequence: | MLDFFTIFSKGGLVLWCFQG VSDSCTGPVNALIRSVLLQE RGGNNSFTHEALTLKYKLDN QFELVFVVGFQKILTLTYVD KLIDDVHRLFRDKYRTEIQQ QSALSLLNGTFDFQNDFLRL LREAEESSKIRAPTTMKKFE DSEKAKKPVRSMIETRGEKP KEKAKNSKKKGAKKEGSDGP LATSKPVPAEKSGLPVGPEN GVELSKEELIRRKREEFIQK |
| Function | Component of the signal recognition particle (SRP) complex receptor (SR). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54. SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. |
| Protein Name | Signal Recognition Particle Receptor Subunit AlphaSr-AlphaDocking Protein AlphaDp-Alpha |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideThought To Be Anchored In The Membrane Through An Interaction With Sr-BetaWhich Contains A Bona Fide Transmembrane Domain |
| Alternative Antibody Names | Anti-Signal Recognition Particle Receptor Subunit Alpha antibodyAnti-Sr-Alpha antibodyAnti-Docking Protein Alpha antibodyAnti-Dp-Alpha antibodyAnti-SRPRA antibodyAnti-SRPR antibody |
Information sourced from Uniprot.org