Anti-SRP54 antibody (400-504) [S1MR] (STJ11103481)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal SRP54 (400-504) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S1MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SRP54 |
| Gene ID | 6729 |
| Uniprot ID | SRP54_HUMAN |
| Immunogen Region | 400-504 |
| Immunogen Sequence | PGRIQRVARGSGVSTRDVQE LLTQYTKFAQMVKKMGGIKG LFKGGDMSKNVSQSQMAKLN QQMAKMMDPRVLHHMGGMAG LQSMMRQFQQGAAGNMKGMM GFNNM |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 400-504 of human SRP54 (P61011). |
Additional Info
| Function | Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane. Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes. Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA. SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER. Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA. Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development. |
| Protein Name | Signal Recognition Particle Subunit Srp54Signal Recognition Particle 54 Kda Protein |
| Database Links | Reactome: R-HSA-1799339 |
| Cellular Localisation | Nucleus SpeckleCytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Signal Recognition Particle Subunit Srp54 antibodyAnti-Signal Recognition Particle 54 Kda Protein antibodyAnti-SRP54 antibody |
Information sourced from Uniprot.org