| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S8MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:2000IF/ICC:1:100-1:400ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SRD5A2 |
| Gene ID: | 6716 |
| Uniprot ID: | S5A2_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen Sequence: | MQVQCQQSPVLAGSATLVAL GALALYVAKPSGYGKHTESL KPAATRLPARAAWFLQELPS FAVPAGILARQPLSLFGPPG TVLLGLFCVHYFHRTFVYSL |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SRD5A2 (P31213). |
| Tissue Specificity | Expressed in high levels in the prostate and many other androgen-sensitive tissues. |
| Function | Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. |
| Protein Name | 3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 25 Alpha-Sr2Sr Type 2Steroid 5-Alpha-Reductase 2S5ar 2Type Ii 5-Alpha Reductase |
| Database Links | Reactome: R-HSA-193048 |
| Cellular Localisation | Microsome MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2 antibodyAnti-5 Alpha-Sr2 antibodyAnti-Sr Type 2 antibodyAnti-Steroid 5-Alpha-Reductase 2 antibodyAnti-S5ar 2 antibodyAnti-Type Ii 5-Alpha Reductase antibodyAnti-SRD5A2 antibody |
Information sourced from Uniprot.org
