| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Spexin (1-50 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPX |
| Gene ID: |
80763 |
| Uniprot ID: |
SPXN_HUMAN |
| Immunogen Region: |
1-50 aa |
| Specificity: |
SPXN Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 1-50 |
| Function | Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release. Spexin-1: Acts as a ligand for galanin receptors GALR2 and GALR3. Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes. Spexin-2: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity. |
| Protein Name | SpexinNpqNeuropeptide QSpexin Hormone Cleaved Into - Spexin-1 - Spexin-2Npq 53-70 |
| Cellular Localisation | SecretedExtracellular SpaceCytoplasmic VesicleSecretory VesicleSecreted Via The Classical Er/Golgi-Dependent Pathway Into The Extracellular Medium Largely As A Full-Length Protein Without The Signal PeptideAnd Not As A Hydrolyzed And Amidated PeptideLocalized Extracellularly Surrounding The Villous Trophoblastic CellsDetected In The Serum |
| Alternative Antibody Names | Anti-Spexin antibodyAnti-Npq antibodyAnti-Neuropeptide Q antibodyAnti-Spexin Hormone Cleaved Into - Spexin-1 - Spexin-2 antibodyAnti-Npq 53-70 antibodyAnti-SPX antibodyAnti-C12orf39 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
