Anti-SPTLC2 antibody (273-323 aa) (STJ193560)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SPTC2 at the amino acid range 273-323
General Information
| Short Description | Rabbit polyclonal anti-Serine palmitoyltransferase 2 (273-323 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SPTLC2 |
| Gene ID | 9517 |
| Uniprot ID | SPTC2_HUMAN |
| Immunogen | Synthesized peptide derived from the human SPTC2 at the amino acid range 273-323 |
| Immunogen Region | 273-323 aa |
| Specificity | This antibody detects endogenous levels of SPTC2 at Human/Mouse |
Additional Info
| Function | Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Crucial for adipogenesis. |
| Protein Name | Serine Palmitoyltransferase 2Long Chain Base Biosynthesis Protein 2Lcb 2Long Chain Base Biosynthesis Protein 2aLcb2aSerine-Palmitoyl-Coa Transferase 2Spt 2 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Serine Palmitoyltransferase 2 antibodyAnti-Long Chain Base Biosynthesis Protein 2 antibodyAnti-Lcb 2 antibodyAnti-Long Chain Base Biosynthesis Protein 2a antibodyAnti-Lcb2a antibodyAnti-Serine-Palmitoyl-Coa Transferase 2 antibodyAnti-Spt 2 antibodyAnti-SPTLC2 antibodyAnti-KIAA0526 antibodyAnti-LCB2 antibody |
Information sourced from Uniprot.org