Anti-Sprouty 2 antibody [R06-7N6] (STJA0036736)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human Sprouty 2
General Information
| Short Description | Rabbit monoclonal anti-Sprouty 2 for use in WB, IHC-P, ICC, IF and IP in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-7N6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:50 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SPRY2 |
| Gene ID | 10253 |
| Uniprot ID | SPY2_HUMAN |
| Immunogen | A synthesized peptide derived from human Sprouty 2 |
Additional Info
| Post Translational Modifications | Cleaved at Pro-144 by the prolyl endopeptidase FAP (seprase) activity (in vitro). |
| Function | Antagonist of fibroblast growth factor (FGF) pathways via inhibition of FGF-mediated phosphorylation of ERK1/2. Thereby acts as an antagonist of FGF-induced retinal lens fiber differentiation, may inhibit limb bud outgrowth and may negatively modulate respiratory organogenesis. Inhibits TGFB-induced epithelial-to-mesenchymal transition in retinal lens epithelial cells. Inhibits CBL/C-CBL-mediated EGFR ubiquitination. |
| Protein Name | Protein Sprouty Homolog 2Spry-2 |
| Database Links | Reactome: R-HSA-1295596Reactome: R-HSA-182971 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffle MembraneAssociated With Microtubules In Unstimulated Cells But Is Translocated To The Membrane Ruffles In Cells Stimulated With Egf (Epidermal Growth Factor) |
| Alternative Antibody Names | Anti-Protein Sprouty Homolog 2 antibodyAnti-Spry-2 antibodyAnti-SPRY2 antibody |
Information sourced from Uniprot.org