| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Glycosylated. |
| Function | Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system. Plays a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis. |
| Protein Name | Signal Peptide Peptidase-Like 2aSpp-Like 2aSppl2aIntramembrane Protease 3Imp-3Presenilin-Like Protein 2 |
| Database Links | Reactome: R-HSA-5357905 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinLysosome MembraneMembraneLumenal SideColocalizes With Palmitoylated And Myristoylated Proteins At The Plasma Membrane |
| Alternative Antibody Names | Anti-Signal Peptide Peptidase-Like 2a antibodyAnti-Spp-Like 2a antibodyAnti-Sppl2a antibodyAnti-Intramembrane Protease 3 antibodyAnti-Imp-3 antibodyAnti-Presenilin-Like Protein 2 antibodyAnti-SPPL2A antibodyAnti-IMP3 antibodyAnti-PSL2 antibodyAnti-PSEC0147 antibody |
Information sourced from Uniprot.org
