| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM41 (421-630) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM41 |
| Gene ID: |
90933 |
| Uniprot ID: |
TRI41_HUMAN |
| Immunogen Region: |
421-630 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 421-630 of human TRIM41 (NP_291027.3). |
| Immunogen Sequence: |
MSRMFCQAARVDLTLDPDTA HPALMLSPDRRGVRLAERRQ EVADHPKRFSADCCVLGAQG FRSGRHYWEVEVGGRRGWAV GAARESTHHKEKVGPGGSSV GSGDASSSRHHHRRRRLHLP QQPLLQREVWCVGTNGKRYQ AQSSTEQTLLSPSEKPRRFG VYLDYEAGRLGFYNAETLAH VHTFSAAFLGERVFPFFRVL SKGTRIKLCP |
| Tissue Specificity | Expressed in multiple tissues with the highest levels in heart and skeletal muscle. |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ligase that plays essential roles in innate antiviral response. Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections. Activates the innate antiviral response by catalyzing monoubiquitination of CGAS, thereby activating CGAS. Also involved in innate antiviral response by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways. Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim41Ring Finger-Interacting Protein With C KinaseRinckTripartite Motif-Containing Protein 41 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim41 antibodyAnti-Ring Finger-Interacting Protein With C Kinase antibodyAnti-Rinck antibodyAnti-Tripartite Motif-Containing Protein 41 antibodyAnti-TRIM41 antibodyAnti-RINCK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
