Host: | Goat |
Applications: | Pep-ELISA/WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-SP140 (29-41) is suitable for use in ELISA and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: | 0.5 mg/mL |
Dilution Range: | WB-1-3µg/ml ELISA-antibody detection limit dilution 1:128000. |
Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: | SP140 |
Gene ID: | 11262 |
Uniprot ID: | SP140_HUMAN |
Immunogen Region: | 29-41 |
Accession Number: | NP_009168.4; NP_001005176.1; NP_001265380.1; NP_001265381.1; NP_001265382.1 |
Specificity: | This antibody is expected to recognize all reported isoforms (NP_009168.4; NP_001005176.1; NP_001265380.1; NP_001265381.1; NP_001265382.1). |
Immunogen Sequence: | EGQNLQEQVCPEP |
Post Translational Modifications | Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727. |
Function | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. |
Protein Name | Nuclear Body Protein Sp140 Lymphoid-Restricted Homolog Of Sp100 Lysp100 Nuclear Autoantigen Sp-140 Speckled 140 Kda |
Cellular Localisation | Nucleus Pml Body Cytoplasm Localized To Nuclear Structures Termed Lands For Lysp100-Associated Nuclear Domains Lands Are Globular Electron-Dense Structures Most Often Found In The Nucleoplasm But Also Found At The Nuclear Membrane And In The Cytoplasm Suggesting That These Structures May Traffic Between The Cytoplasm And The Nucleus Also Colocalizes With Pml In A Subset Of Pml Nuclear Bodies |
Alternative Antibody Names | Anti-Nuclear Body Protein Sp140 antibody Anti-Lymphoid-Restricted Homolog Of Sp100 antibody Anti-Lysp100 antibody Anti-Nuclear Autoantigen Sp-140 antibody Anti-Speckled 140 Kda antibody Anti-SP140 antibody Anti-LYSP100 antibody |
Information sourced from Uniprot.org