| Tissue Specificity | Expressed in exocrine cells and islets of Langerhans in the pancreas (at protein level). Expressed in the pancreas, placenta, kidney, brain, heart, lung, and liver. Expressed in adipose tissue, cervix, colon, esophagus, ovary, prostate, small intestine, spleen, testicle, thymus and thyroid. |
| Function | Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3'. Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube. Binds to the gene promoter of MBP and acts as a transcriptional repressor. Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells. Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells. Promotes brown adipocyte differentiation. Inhibitor of WNT signaling. |
| Protein Name | Transcription Factor Sox-13Islet Cell Antigen 12SrySex Determining Region Y-Box 13Type 1 Diabetes Autoantigen Ica12 |
| Database Links | Reactome: R-HSA-3769402 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Transcription Factor Sox-13 antibodyAnti-Islet Cell Antigen 12 antibodyAnti-Sry antibodyAnti-Sex Determining Region Y-Box 13 antibodyAnti-Type 1 Diabetes Autoantigen Ica12 antibodyAnti-SOX13 antibody |
Information sourced from Uniprot.org
