Anti-SORBS2 antibody (794-844 aa) (STJ195823)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SRBS2 at the amino acid range 794-844
General Information
| Short Description | Rabbit polyclonal anti-Sorbin and SH3 domain-containing protein 2 (794-844 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SORBS2 |
| Gene ID | 8470 |
| Uniprot ID | SRBS2_HUMAN |
| Immunogen | Synthesized peptide derived from the human SRBS2 at the amino acid range 794-844 |
| Immunogen Region | 794-844 aa |
| Specificity | This antibody detects endogenous levels of SRBS2 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Ubiquitinated by CBL. Dephosphorylated by PTPN12. |
| Function | Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. |
| Protein Name | Sorbin And Sh3 Domain-Containing Protein 2Arg-Binding Protein 2Argbp2Arg/Abl-Interacting Protein 2Sorbin |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionApical Cell MembraneCell JunctionFocal AdhesionCell ProjectionLamellipodiumFound At The Z-Disk SarcomeresStress FibersDense Bodies And Focal AdhesionIn Pancreatic Acinar CellsLocalized Preferentially To The Apical MembraneColocalized With Vinculin And Filamentous Actin At Focal Adhesions And Lamellipodia Of Pancreatic Cells |
| Alternative Antibody Names | Anti-Sorbin And Sh3 Domain-Containing Protein 2 antibodyAnti-Arg-Binding Protein 2 antibodyAnti-Argbp2 antibodyAnti-Arg/Abl-Interacting Protein 2 antibodyAnti-Sorbin antibodyAnti-SORBS2 antibodyAnti-ARGBP2 antibodyAnti-KIAA0777 antibody |
Information sourced from Uniprot.org