Anti-SOCS4 antibody (426-440) (STJ110310)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SOCS4 (426-440) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SOCS4 |
| Gene ID | 122809 |
| Uniprot ID | SOCS4_HUMAN |
| Immunogen Region | 426-440 |
| Immunogen Sequence | HNFSFDAHDPCVFHSPDITG LLEHYKDPSACMFFEPLLST PLIRTFPFSLQHICRTVICN CTTYDGIDALPIPSSMKLYL KEYHYKSKVRVLRIDAPEQQ C |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 340-440 of human SOCS4 (NP_543143.1). |
Additional Info
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. |
| Protein Name | Suppressor Of Cytokine Signaling 4Socs-4Suppressor Of Cytokine Signaling 7Socs-7 |
| Database Links | Reactome: R-HSA-8939242 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 4 antibodyAnti-Socs-4 antibodyAnti-Suppressor Of Cytokine Signaling 7 antibodyAnti-Socs-7 antibodyAnti-SOCS4 antibodyAnti-SOCS7 antibody |
Information sourced from Uniprot.org