| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SOCS3 (1-225) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOCS3 |
| Gene ID: |
9021 |
| Uniprot ID: |
SOCS3_HUMAN |
| Immunogen Region: |
1-225 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-225 of human SOCS3 (NP_003946.3). |
| Immunogen Sequence: |
MVTHSKFPAAGMSRPLDTSL RLKTFSSKSEYQLVVNAVRK LQESGFYWSAVTGGEANLLL SAEPAGTFLIRDSSDQRHFF TLSVKTQSGTKNLRIQCEGG SFSLQSDPRSTQPVPRFDCV LKLVHHYMPPPGAPSFPSPP TEPSSEVPEQPSAQPLPGSP PRRAYYIYSGGEKIPLVLSR PLSSNVATLQHLCRKTVNGH LDSYEKVTQLPGPIREFLDQ YDAPL |
| Tissue Specificity | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| Post Translational Modifications | Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. |
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 3Socs-3Cytokine-Inducible Sh2 Protein 3Cis-3Stat-Induced Stat Inhibitor 3Ssi-3 |
| Database Links | Reactome: R-HSA-1059683Reactome: R-HSA-2586552Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-8849474Reactome: R-HSA-8939242Reactome: R-HSA-8951664Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9705462Reactome: R-HSA-982772Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 3 antibodyAnti-Socs-3 antibodyAnti-Cytokine-Inducible Sh2 Protein 3 antibodyAnti-Cis-3 antibodyAnti-Stat-Induced Stat Inhibitor 3 antibodyAnti-Ssi-3 antibodyAnti-SOCS3 antibodyAnti-CIS3 antibodyAnti-SSI3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
