• STJ70014 (8µg/ml) staining of paraffin embedded Human Kidney. Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
  • STJ70014 Negative Control showing staining of paraffin embedded Human Kidney, with no primary antibody.
  • STJ70014 (10µg/ml) : Staining of paraffin embedded Mouse Kidney. Heat induced antigen retrieval with citrate buffer pH 6, HRP-Staining (1:500).
  • STJ70014 Negative Control showing staining of paraffin embedded Mouse Kidney, with no primary antibody.
  • STJ70014 Immunofluorescence analysis of paraformaldehyde fixed MCF7 cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing cytoplasmic and nuclear staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).
  • STJ70014 Flow cytometric analysis of paraformaldehyde fixed HEK293 cells (blue line) , permeabilized with 0. 5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.

Anti-SOCS1 antibody (C-Term) (STJ70014)

SKU:
STJ70014-100

£303.50
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Host: Goat
Applications: Pep-ELISA/FC/IF/IHC
Reactivity: Human/Mouse/Dog/Cow/Rat/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SOCS1 (C-Term) is suitable for use in ELISA, Flow Cytometry, Immunofluorescence and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-8µg/ml, 5-10µg/ml
IF-Expression of the protein seen in the cytoplasm and nucleus of MCF7 cells. 10µg/ml
ELISA-antibody detection limit dilution 1:4000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SOCS1
Gene ID: 8651
Uniprot ID: SOCS1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_003736.1
Immunogen Sequence: VLRDYLSSFPFQI
Function Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 1
Socs-1
Jak-Binding Protein
Jab
Stat-Induced Stat Inhibitor 1
Ssi-1
Tec-Interacting Protein 3
Tip-3
Database Links Reactome: R-HSA-1266695
Reactome: R-HSA-1433559
Reactome: R-HSA-166058
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-909733
Reactome: R-HSA-912694
Reactome: R-HSA-9674555
Reactome: R-HSA-9705462
Reactome: R-HSA-982772
Reactome: R-HSA-983168
Cellular Localisation Nucleus
Cytoplasmic Vesicle
Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3
Alternative Antibody Names Anti-Suppressor Of Cytokine Signaling 1 antibody
Anti-Socs-1 antibody
Anti-Jak-Binding Protein antibody
Anti-Jab antibody
Anti-Stat-Induced Stat Inhibitor 1 antibody
Anti-Ssi-1 antibody
Anti-Tec-Interacting Protein 3 antibody
Anti-Tip-3 antibody
Anti-SOCS1 antibody
Anti-SSI1 antibody
Anti-TIP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance