Anti-SOCS1 antibody (49-98 aa) (STJ95727)

SKU:
STJ95727
£48.00 - £252.00
Processing The item has been added

Host: Rabbit
Applications: IF/WB/IHC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Suppressor of cytokine signaling 1 (49-98 aa) is suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IF 1:50-200
WB 1:500-2000
ELISA 1:10000-20000
IHC 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SOCS1
Gene ID: 8651
Uniprot ID: SOCS1_HUMAN
Immunogen Region: 49-98 aa
Specificity: SOCS-1 Polyclonal Antibody detects endogenous levels of SOCS-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human SOCS-1 at the amino acid range 49-98
Function Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 1
Socs-1
Jak-Binding Protein
Jab
Stat-Induced Stat Inhibitor 1
Ssi-1
Tec-Interacting Protein 3
Tip-3
Database Links Reactome: R-HSA-1266695
Reactome: R-HSA-1433559
Reactome: R-HSA-166058
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-909733
Reactome: R-HSA-912694
Reactome: R-HSA-9674555
Reactome: R-HSA-9705462
Reactome: R-HSA-982772
Reactome: R-HSA-983168
Cellular Localisation Nucleus
Cytoplasmic Vesicle
Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3
Alternative Antibody Names Anti-Suppressor Of Cytokine Signaling 1 antibody
Anti-Socs-1 antibody
Anti-Jak-Binding Protein antibody
Anti-Jab antibody
Anti-Stat-Induced Stat Inhibitor 1 antibody
Anti-Ssi-1 antibody
Anti-Tec-Interacting Protein 3 antibody
Anti-Tip-3 antibody
Anti-SOCS1 antibody
Anti-SSI1 antibody
Anti-TIP3 antibody

Information sourced from Uniprot.org