| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SOCS1 |
| Gene ID: | 8651 |
| Uniprot ID: | SOCS1_HUMAN |
| Immunogen Region: | 1-211 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human SOCS1 (NP_003736.1). |
| Immunogen Sequence: | MVAHNQVAADNAVSTAAEPR RRPEPSSSSSSSPAAPARPR PCPAVPAPAPGDTHFRTFRS HADYRRITRASALLDACGFY WGPLSVHGAHERLRAEPVGT |
| Tissue Specificity | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. |
| Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 1 Socs-1 Jak-Binding Protein Jab Stat-Induced Stat Inhibitor 1 Ssi-1 Tec-Interacting Protein 3 Tip-3 |
| Database Links | Reactome: R-HSA-1266695 Reactome: R-HSA-1433559 Reactome: R-HSA-166058 Reactome: R-HSA-6785807 Reactome: R-HSA-877300 Reactome: R-HSA-877312 Reactome: R-HSA-909733 Reactome: R-HSA-912694 Reactome: R-HSA-9674555 Reactome: R-HSA-9705462 Reactome: R-HSA-982772 Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus Cytoplasmic Vesicle Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 1 antibody Anti-Socs-1 antibody Anti-Jak-Binding Protein antibody Anti-Jab antibody Anti-Stat-Induced Stat Inhibitor 1 antibody Anti-Ssi-1 antibody Anti-Tec-Interacting Protein 3 antibody Anti-Tip-3 antibody Anti-SOCS1 antibody Anti-SSI1 antibody Anti-TIP3 antibody |
Information sourced from Uniprot.org