| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNRPD1 |
| Gene ID: | 6632 |
| Uniprot ID: | SMD1_HUMAN |
| Immunogen Region: | 1-96 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-96 of human SNRPD1 (NP_008869.1). |
| Immunogen Sequence: | MKLVRFLMKLSHETVTIELK NGTQVHGTITGVDVSMNTHL KAVKMTLKNREPVQLETLSI RGNNIRYFILPDSLPLDTLL VDVEPKVKSKKREAVA |
| Post Translational Modifications | Methylated on arginine residues by PRMT5 and PRMT7.probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. |
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. |
| Protein Name | Small Nuclear Ribonucleoprotein Sm D1 Sm-D1 Sm-D Autoantigen Snrnp Core Protein D1 |
| Database Links | Reactome: R-HSA-191859 Reactome: R-HSA-72163 Reactome: R-HSA-72165 Reactome: R-HSA-9754678 |
| Cellular Localisation | Cytoplasm Cytosol Nucleus Smn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes |
| Alternative Antibody Names | Anti-Small Nuclear Ribonucleoprotein Sm D1 antibody Anti-Sm-D1 antibody Anti-Sm-D Autoantigen antibody Anti-Snrnp Core Protein D1 antibody Anti-SNRPD1 antibody |
Information sourced from Uniprot.org