| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMYD2 (1-270) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMYD2 |
| Gene ID: |
56950 |
| Uniprot ID: |
SMYD2_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human SMYD2 (NP_064582.2). |
| Immunogen Sequence: |
MRAEGLGGLERFCSPGKGRG LRALQPFQVGDLLFSCPAYA YVLTVNERGNHCEYCFTRKE GLSKCGRCKQAFYCNVECQK EDWPMHKLECSPMVVFGENW NPSETVRLTARILAKQKIHP ERTPSEKLLAVKEFESHLDK LDNEKKDLIQSDIAALHHFY SKHLGFPDNDSLVVLFAQVN CNGFTIEDEELSHLGSAIFP DVALMNHSCCPNVIVTYKGT LAEVRAVQEIKPGEEVFTS |
| Function | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'. |
| Protein Name | N-Lysine Methyltransferase Smyd2Hskm-BHistone Methyltransferase Smyd2Lysine N-Methyltransferase 3cSet And Mynd Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-3214841Reactome: R-HSA-6804760 |
| Cellular Localisation | CytoplasmCytosolNucleus |
| Alternative Antibody Names | Anti-N-Lysine Methyltransferase Smyd2 antibodyAnti-Hskm-B antibodyAnti-Histone Methyltransferase Smyd2 antibodyAnti-Lysine N-Methyltransferase 3c antibodyAnti-Set And Mynd Domain-Containing Protein 2 antibodyAnti-SMYD2 antibodyAnti-KMT3C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
