• Western blot analysis of lysates from K562 cells, using Brm antibody.
  • Western blot analysis of extracts from A549 cells, using Brm Polyclonal Antibody.. Secondary antibody was diluted at 1:20000 cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-SMARCA2 antibody (1328-1377 aa) (STJ96404)

SKU:
STJ96404

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Probable global transcription activator SNF2L2 (1328-1377 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SMARCA2
Gene ID: 6595
Uniprot ID: SMCA2_HUMAN
Immunogen Region: 1328-1377 aa
Specificity: Brm Polyclonal Antibody detects endogenous levels of Brm protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Brm at the amino acid range 1328-1377
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Protein Name Probable Global Transcription Activator Snf2l2
Atp-Dependent Helicase Smarca2
Brg1-Associated Factor 190b
Baf190b
Protein Brahma Homolog
Hbrm
Snf2-Alpha
Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 2
Database Links Reactome: R-HSA-3214858
Reactome: R-HSA-8939243
Cellular Localisation Nucleus
Localizes To Sites Of Dna Damage
Alternative Antibody Names Anti-Probable Global Transcription Activator Snf2l2 antibody
Anti-Atp-Dependent Helicase Smarca2 antibody
Anti-Brg1-Associated Factor 190b antibody
Anti-Baf190b antibody
Anti-Protein Brahma Homolog antibody
Anti-Hbrm antibody
Anti-Snf2-Alpha antibody
Anti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily A Member 2 antibody
Anti-SMARCA2 antibody
Anti-BAF190B antibody
Anti-BRM antibody
Anti-SNF2A antibody
Anti-SNF2L2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance