| Short Description : | Rabbit monoclonal anti-Ribonuclease Slfn12 for use in WB and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/FC |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | PT0798R |
| Isotype: | IgGk |
| Conjugation: | Unconjugated |
| Purification: | Protein A |
| Dilution Range: | WB 1:1000-5000FC 1:100-300 |
| Formulation: | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLFN12 |
| Gene ID: | 55106 |
| Uniprot ID: | SLN12_HUMAN |
| Specificity: | Endogenous |
| Function | Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. May play a role in cell differentiation. |
| Protein Name | Ribonuclease Slfn12Schlafen Family Member 12 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Ribonuclease Slfn12 antibodyAnti-Schlafen Family Member 12 antibodyAnti-SLFN12 antibody |
Information sourced from Uniprot.org
