Anti-SLFN12 antibody (51-101 aa) (STJ193855)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SLN12 at the amino acid range 51-101
General Information
| Short Description | Rabbit polyclonal anti-Ribonuclease SLFN12 (51-101 aa) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLFN12 |
| Gene ID | 55106 |
| Uniprot ID | SLN12_HUMAN |
| Immunogen | Synthesized peptide derived from the human SLN12 at the amino acid range 51-101 |
| Immunogen Region | 51-101 aa |
| Specificity | This antibody detects endogenous levels of SLN12 at Human |
Additional Info
| Function | Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. May play a role in cell differentiation. |
| Protein Name | Ribonuclease Slfn12Schlafen Family Member 12 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Ribonuclease Slfn12 antibodyAnti-Schlafen Family Member 12 antibodyAnti-SLFN12 antibody |
Information sourced from Uniprot.org