Anti-SLC9A9 antibody (2-50 aa) (STJ13102279)

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STJ13102279-100
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Host: Rabbit
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-SLC9A9 (2-50 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilised
Purification: IgG purified
Dilution Range: IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Storage Instruction: Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Gene Symbol: SLC9A9
Gene ID: 285195
Uniprot ID: SL9A9_HUMAN
Immunogen Region: 2-50 aa
Specificity: Specific for SLC9A9.
Immunogen: A synthetic peptide from aa region of 2-50 of human SLC9A9 conjugated to blue carrier protein was used as the antigen.
Function Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain. Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH.
Protein Name Sodium/Hydrogen Exchanger 9
Na(+/H(+ Exchanger 9
Nhe-9
Solute Carrier Family 9 Member 9
Database Links Reactome: R-HSA-425986
Reactome: R-HSA-5619052
Cellular Localisation Late Endosome Membrane
Multi-Pass Membrane Protein
Early Endosome Membrane
Recycling Endosome Membrane
Cell Membrane
Cytoplasmic Vesicle
Phagosome Membrane
Localized To The Plasma Membrane In Inner Ear Hair Cell Bundle
Alternative Antibody Names Anti-Sodium/Hydrogen Exchanger 9 antibody
Anti-Na(+/H(+ Exchanger 9 antibody
Anti-Nhe-9 antibody
Anti-Solute Carrier Family 9 Member 9 antibody
Anti-SLC9A9 antibody
Anti-NHE9 antibody
Anti-Nbla00118 antibody

Information sourced from Uniprot.org