Anti-SLC9A9 antibody (2-50 aa) (STJ13102279)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region of 2-50 of human SLC9A9 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC9A9 (2-50 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC9A9 |
| Gene ID | 285195 |
| Uniprot ID | SL9A9_HUMAN |
| Immunogen | A synthetic peptide from aa region of 2-50 of human SLC9A9 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 2-50 aa |
| Specificity | Specific for SLC9A9. |
Additional Info
| Function | Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (Probable). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, e.g., endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters. Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain. Regulates synaptic transmission by regulating the luminal pH of axonal endosomes. Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages. Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracelular pH. |
| Protein Name | Sodium/Hydrogen Exchanger 9Na(+/H(+ Exchanger 9Nhe-9Solute Carrier Family 9 Member 9 |
| Database Links | Reactome: R-HSA-425986Reactome: R-HSA-5619052 |
| Cellular Localisation | Late Endosome MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneRecycling Endosome MembraneCell MembraneCytoplasmic VesiclePhagosome MembraneLocalized To The Plasma Membrane In Inner Ear Hair Cell Bundle |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 9 antibodyAnti-Na(+/H(+ Exchanger 9 antibodyAnti-Nhe-9 antibodyAnti-Solute Carrier Family 9 Member 9 antibodyAnti-SLC9A9 antibodyAnti-NHE9 antibodyAnti-Nbla00118 antibody |
Information sourced from Uniprot.org