Anti-SLC9A4 antibody (C-Term) (STJ13102117)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from c-terminal region of human SLC9A4 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
General Information
| Short Description | Rabbit polyclonal anti-SLC9A4 (C-Term) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC9A4 |
| Gene ID | 389015 |
| Uniprot ID | SL9A4_HUMAN |
| Immunogen | A synthetic peptide from c-terminal region of human SLC9A4 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Immunogen Region | C-Term |
| Specificity | Specific for SLC9A4. |
Additional Info
| Function | Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions. As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion. Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion. Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids. |
| Protein Name | Sodium/Hydrogen Exchanger 4Na(+/H(+ Exchanger 4Nhe-4Solute Carrier Family 9 Member 4 |
| Database Links | Reactome: R-HSA-425986 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneZymogen Granule MembraneEnrichment At Apical Or Basolateral Membrane May Be Tissue-Dependent |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 4 antibodyAnti-Na(+/H(+ Exchanger 4 antibodyAnti-Nhe-4 antibodyAnti-Solute Carrier Family 9 Member 4 antibodyAnti-SLC9A4 antibodyAnti-NHE4 antibody |
Information sourced from Uniprot.org