Anti-SLC7A8 antibody (C-Term) (STJ13102149)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from c-terminal region of mouse Large neutral amino acids transporter small subunit 2 (SLC7A8, LAT2) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SLC7A8 (C-Term) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Slc7a8 |
| Gene ID | 50934 |
| Uniprot ID | LAT2_MOUSE |
| Immunogen | A synthetic peptide from c-terminal region of mouse Large neutral amino acids transporter small subunit 2 (SLC7A8, LAT2) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for SLC7A8. |
Additional Info
| Function | Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4). Mediates the uptake of L-DOPA. May participate in auditory function. |
| Protein Name | Large Neutral Amino Acids Transporter Small Subunit 2L-Type Amino Acid Transporter 2Mlat2Solute Carrier Family 7 Member 8 |
| Database Links | Reactome: R-MMU-210991Reactome: -MMU-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneWhen Coexpressed With Slc3a2/4f2hcIs Localized To The Plasma MembraneColocalized With Slc3a2/4f2hc At The Basolateral Membrane Of Kidney Cortex Proximal Tubules And Small Intestine Epithelia Of The Villi |
| Alternative Antibody Names | Anti-Large Neutral Amino Acids Transporter Small Subunit 2 antibodyAnti-L-Type Amino Acid Transporter 2 antibodyAnti-Mlat2 antibodyAnti-Solute Carrier Family 7 Member 8 antibodyAnti-Slc7a8 antibodyAnti-Lat2 antibody |
Information sourced from Uniprot.org