| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SLC7A6 |
| Gene ID: |
9057 |
| Uniprot ID: |
YLAT2_HUMAN |
| Immunogen Region: |
456-515 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 456-515 of human SLC7A6 (NP_003974.3). |
| Immunogen Sequence: |
GIALSGVPFYFMGVYLPESR RPLFIRNVLAAITRGTQQLC FCVLTELDVAEEKKDERKTD |
| Tissue Specificity | Expressed in normal fibroblasts and those from LPI patients. Also expressed in HUVECs, monocytes, RPE cells, and various carcinoma cell lines. Expressed in brain, heart, testis, kidney, small intestine and parotis. Highly expressed in T lymphocytes. |
| Function | Heterodimer with SLC3A2, that functions as an antiporter which operates as an efflux route by exporting cationic amino acids such as L-arginine from inside the cells in exchange with neutral amino acids like L-leucine, L-glutamine and isoleucine, plus sodium ions and may participate in nitric oxide synthesis. Also exchanges L-arginine with L-lysine in a sodium-independent manner. The transport mechanism is electroneutral and operates with a stoichiometry of 1:1. Contributes to ammonia-induced increase of L-arginine uptake in cerebral cortical astrocytes leading to ammonia-dependent increase of nitric oxide (NO) production via inducible nitric oxide synthase (iNOS) induction, and protein nitration. May mediate transport of ornithine in retinal pigment epithelial (RPE) cells. May also transport glycine betaine in a sodium dependent manner from the cumulus granulosa into the enclosed oocyte. |
| Protein Name | Y+L Amino Acid Transporter 2Cationic Amino Acid Transporter - Y+ SystemSolute Carrier Family 7 Member 6Y(+L-Type Amino Acid Transporter 2Y+Lat2Y+Lat-2 |
| Database Links | Reactome: R-HSA-210991Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Y+L Amino Acid Transporter 2 antibodyAnti-Cationic Amino Acid Transporter - Y+ System antibodyAnti-Solute Carrier Family 7 Member 6 antibodyAnti-Y(+L-Type Amino Acid Transporter 2 antibodyAnti-Y+Lat2 antibodyAnti-Y+Lat-2 antibodyAnti-SLC7A6 antibodyAnti-KIAA0245 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
