Anti-SLC7A10 antibody (450-500) {FITC} (STJ500168)

SKU:
STJ500168-100

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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC7A10 (450-500) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50-0.75 µg/µl
Dilution Range: WB: 1:500-1:1, 000
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:200
IHC: 1:50
ICC: 1:50
IF: 1:50
CFM: 1:50
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC7A10
Gene ID: 56301
Uniprot ID: AAA1_HUMAN
Immunogen Region: 450-500
Immunogen: Synthetic peptide taken within amino acid region 450-500 on rat Asc-type amino acid transporter 1 protein.
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
Function Associates with SLC3A2/4F2hc to form a functional heterodimeric complex that translocates small neutral L- and D-amino acids across the plasma membrane. Preferentially mediates exchange transport, but can also operate via facilitated diffusion. Acts as a major transporter for glycine, L- and D-serine in the central nervous system. At the spinal cord and brainstem regulates glycine metabolism and glycinergic inhibitory neurotransmission by providing for glycine de novo synthesis from L-serine and glycine recycling from astrocytes to glycinergic motor neurons. At Schaffer collateral-CA1 synapses mediates D-serine and glycine release that modulates post-synaptic activation of NMDA receptors and excitatory glutamatergic transmission. May regulate D-serine release from mesenchymal progenitors located in developing subcutaneous adipose tissue, favoring white adipocyte over thermogenic beige adipocyte lineage commitment.
Protein Name Asc-Type Amino Acid Transporter 1
Asc-1
Solute Carrier Family 7 Member 10
Database Links Reactome: R-HSA-210991
Reactome: R-HSA-352230
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Colocalizes With Olig2 In Astrocytic Processes
Localizes To The Plasma Membrane In Mature Adipocytes And To Intracellular Structures In Preadipocytes
Alternative Antibody Names Anti-Asc-Type Amino Acid Transporter 1 antibody
Anti-Asc-1 antibody
Anti-Solute Carrier Family 7 Member 10 antibody
Anti-SLC7A10 antibody
Anti-ASC1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance