Anti-SLC5A1 antibody (5-50 aa) (STJ13102195)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 5-50 of extracellular domain of mouse SLC5A1 conjugated to blue carrier protein was used as the antigen. The peptide shares about 93% identity with rat sequence.
General Information
| Short Description | Rabbit polyclonal anti-SLC5A1 (5-50 aa) for use in IHC and WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Slc5a1 |
| Gene ID | 20537 |
| Uniprot ID | SC5A1_MOUSE |
| Immunogen | A synthetic peptide from aa region 5-50 of extracellular domain of mouse SLC5A1 conjugated to blue carrier protein was used as the antigen. The peptide shares about 93% identity with rat sequence. |
| Immunogen Region | 5-50 aa |
| Specificity | Specific for SLC5A1. |
Additional Info
| Post Translational Modifications | N-glycosylation is not necessary for the cotransporter function. |
| Function | Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump. Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis. Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules. Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception. Acts as a water channel enabling passive water transport in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity comparable to aquaporins and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. |
| Protein Name | Sodium/Glucose Cotransporter 1Na(+/Glucose Cotransporter 1High Affinity Sodium-Glucose CotransporterSolute Carrier Family 5 Member 1 |
| Database Links | Reactome: R-MMU-189200Reactome: -MMU-8981373 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sodium/Glucose Cotransporter 1 antibodyAnti-Na(+/Glucose Cotransporter 1 antibodyAnti-High Affinity Sodium-Glucose Cotransporter antibodyAnti-Solute Carrier Family 5 Member 1 antibodyAnti-Slc5a1 antibodyAnti-Nagt antibodyAnti-Sglt1 antibody |
Information sourced from Uniprot.org