Anti-SLC39A9 antibody (101-150 aa) (STJ96316)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SLC39A9 at the amino acid range 101-150
General Information
| Short Description | Rabbit polyclonal anti-Zinc transporter ZIP9 (101-150 aa) for use in WB and ELISA in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC39A9 |
| Gene ID | 55334 |
| Uniprot ID | S39A9_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SLC39A9 at the amino acid range 101-150 |
| Immunogen Region | 101-150 aa |
| Specificity | ZIP9 Polyclonal Antibody detects endogenous levels of ZIP9 protein. |
Additional Info
| Function | Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation. Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1. This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells. Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process. |
| Protein Name | Zinc Transporter Zip9Solute Carrier Family 39 Member 9Zrt- And Irt-Like Protein 9Zip-9 |
| Database Links | |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneCell MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear RegionMitochondrionNucleus |
| Alternative Antibody Names | Anti-Zinc Transporter Zip9 antibodyAnti-Solute Carrier Family 39 Member 9 antibodyAnti-Zrt- And Irt-Like Protein 9 antibodyAnti-Zip-9 antibodyAnti-SLC39A9 antibodyAnti-ZIP9 antibodyAnti-UNQ714 antibodyAnti-PRO1377 antibody |
Information sourced from Uniprot.org