| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC27A4 |
| Gene ID: | 10999 |
| Uniprot ID: | S27A4_HUMAN |
| Immunogen Region: | 494-643 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 494-643 of human FATP4/SLC27A4 (NP_005085.2). |
| Immunogen Sequence: | DELGYLYFRDRTGDTFRWKG ENVSTTEVEGTLSRLLDMAD VAVYGVEVPGTEGRAGMAAV ASPTGNCDLERFAQVLEKEL PLYARPIFLRLLPELHKTGT YKFQKTELRKEGFDPAIVKD PLFYLDAQKGRYVPLDQEAY SRIQAGEEKL |
| Tissue Specificity | Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue. Expressed in brain gray matter. |
| Function | Mediates the levels of long-chain fatty acids (LCFA) in the cell by facilitating their transport across cell membranes. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 4 Fatp-4 Fatty Acid Transport Protein 4 Arachidonate--Coa Ligase Long-Chain-Fatty-Acid--Coa Ligase Solute Carrier Family 27 Member 4 Very Long-Chain Acyl-Coa Synthetase 4 Acsvl4 |
| Database Links | Reactome: R-HSA-5619108 Reactome: R-HSA-804914 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 4 antibody Anti-Fatp-4 antibody Anti-Fatty Acid Transport Protein 4 antibody Anti-Arachidonate--Coa Ligase antibody Anti-Long-Chain-Fatty-Acid--Coa Ligase antibody Anti-Solute Carrier Family 27 Member 4 antibody Anti-Very Long-Chain Acyl-Coa Synthetase 4 antibody Anti-Acsvl4 antibody Anti-SLC27A4 antibody Anti-ACSVL4 antibody Anti-FATP4 antibody |
Information sourced from Uniprot.org
