Anti-SLC27A1 antibody (115-165 aa) (STJ195582)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human S27A1 at the amino acid range 115-165
General Information
| Short Description | Rabbit polyclonal anti-Long-chain fatty acid transport protein 1 (115-165 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC27A1 |
| Gene ID | 376497 |
| Uniprot ID | S27A1_HUMAN |
| Immunogen | Synthesized peptide derived from the human S27A1 at the amino acid range 115-165 |
| Immunogen Region | 115-165 aa |
| Specificity | This antibody detects endogenous levels of S27A1 at Human/Mouse/Rat |
Additional Info
| Function | Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane. Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier. |
| Protein Name | Long-Chain Fatty Acid Transport Protein 1Arachidonate--Coa LigaseFatty Acid Transport Protein 1Fatp-1Long-Chain-Fatty-Acid--Coa LigaseSolute Carrier Family 27 Member 1Very Long-Chain Acyl-Coa Synthetase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2142753Reactome: R-HSA-804914 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndomembrane SystemCytoplasmPlasma Membrane And Intracellular MembranesAt Least In AdipocytesIn AdipocytesBut Not MyocytesInsulin Via The Mtorc1 Signaling Pathway Induces A Rapid Translocation Of Slc27a1 From Intracellular Compartments To The Plasma MembraneParalleled By Increased Lcfa UptakeInsulin-Dependent Translocation From The Cytoplasm To The Cell Membrane Is Regulated By Eprs1Predominantly Cytoplasmic In Myocytes |
| Alternative Antibody Names | Anti-Long-Chain Fatty Acid Transport Protein 1 antibodyAnti-Arachidonate--Coa Ligase antibodyAnti-Fatty Acid Transport Protein 1 antibodyAnti-Fatp-1 antibodyAnti-Long-Chain-Fatty-Acid--Coa Ligase antibodyAnti-Solute Carrier Family 27 Member 1 antibodyAnti-Very Long-Chain Acyl-Coa Synthetase antibodyAnti-SLC27A1 antibodyAnti-ACSVL5 antibodyAnti-FATP1 antibody |
Information sourced from Uniprot.org