Immunofluorescence analysis of U-2 OS cells using SLC25A27 Rabbit polyclonal antibody (STJ115776) at dilution of 1:100. Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.

Anti-SLC25A27 antibody (258-275) (STJ115776)

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STJ115776
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Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SLC25A27
Gene ID: 9481
Uniprot ID: UCP4_HUMAN
Immunogen Region: 258-275
Specificity: A synthetic peptide corresponding to a sequence within amino acids 201-300 of human SLC25A27 (NP_004268.3).
Immunogen Sequence: ALVNMGDLTTYDTVKHYLVL NTPLEDNIMTHGLSSLCSGL VASILGTPADVIKSRIMNQP RDKQGRGLLYKSSTDCLIQA VQGEGFMSLYKGFLPSWLRM TPWSMVFWLTYEKIREMSGV SPF
Tissue Specificity Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra.
Function Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated.
Protein Name Mitochondrial Uncoupling Protein 4
Ucp 4
Solute Carrier Family 25 Member 27
Database Links Reactome: R-HSA-167826
Cellular Localisation Mitochondrion Inner Membrane
Multi-Pass Membrane Protein
Localizes To Neuronal Cell Body And Processes
Within Mitochondrial Inner Membrane
It Is Mainly Observed In The Inner Boundary Membrane Locally Separated From F(1)F(0) Atp Synthase
Which Is Preferentially Localized In Cristae
Alternative Antibody Names Anti-Mitochondrial Uncoupling Protein 4 antibody
Anti-Ucp 4 antibody
Anti-Solute Carrier Family 25 Member 27 antibody
Anti-SLC25A27 antibody
Anti-UCP4 antibody
Anti-UNQ772 antibody
Anti-PRO1566 antibody

Information sourced from Uniprot.org

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