| Function | Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. |
| Protein Name | Solute Carrier Family 22 Member 1724p3 Receptor24p3rBrain-Type Organic Cation TransporterLipocalin-2 ReceptorNeutrophil Gelatinase-Associated Lipocalin ReceptorNgalr |
| Database Links | Reactome: R-HSA-917937 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinVacuole MembraneUpon Lcn2-BindingIt Is Internalized |
| Alternative Antibody Names | Anti-Solute Carrier Family 22 Member 17 antibodyAnti-24p3 Receptor antibodyAnti-24p3r antibodyAnti-Brain-Type Organic Cation Transporter antibodyAnti-Lipocalin-2 Receptor antibodyAnti-Neutrophil Gelatinase-Associated Lipocalin Receptor antibodyAnti-Ngalr antibodyAnti-SLC22A17 antibodyAnti-BOCT antibodyAnti-BOIT antibody |
Information sourced from Uniprot.org
