| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC12A2 |
| Gene ID: | 6558 |
| Uniprot ID: | S12A2_HUMAN |
| Immunogen Region: | 120-1212 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-280 of human SLC12A2 (NP_001037.1). |
| Immunogen Sequence: | GEASGESEPAKGSEEAKGRF RVNFVDPAASSSAEDSLSDA AGVGVDGPNVSFQNGGDTVL SEGSSLHSGGGGGSGHHQHY YYDTHTNTYYLRTFGHNTMD AVPRIDHYRHTAAQLGEKLL RPSLAELHDELEKEPFEDGF ANGEESTPTRDAVVTYTAES K |
| Tissue Specificity | Expressed in many tissues. |
| Post Translational Modifications | Phosphorylated at Thr-203, Thr-207 and Thr-212 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), promoting its activity. |
| Function | Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane. Plays a vital role in the regulation of ionic balance and cell volume. |
| Protein Name | Solute Carrier Family 12 Member 2Basolateral Na-K-Cl SymporterBumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 2Bsc2Na-K-2cl Cotransporter 1Hnkcc1 |
| Database Links | Reactome: R-HSA-426117 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Solute Carrier Family 12 Member 2 antibodyAnti-Basolateral Na-K-Cl Symporter antibodyAnti-Bumetanide-Sensitive Sodium-(Potassium-Chloride Cotransporter 2 antibodyAnti-Bsc2 antibodyAnti-Na-K-2cl Cotransporter 1 antibodyAnti-Hnkcc1 antibodyAnti-SLC12A2 antibodyAnti-NKCC1 antibody |
Information sourced from Uniprot.org