| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SIVA1 |
| Gene ID: | 10572 |
| Uniprot ID: | SIVA_HUMAN |
| Immunogen Region: | 1-110 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human SIVA1 (NP_068355.1). |
| Immunogen Sequence: | MPKRSCPFADVAPLQLKVRV SQRELSRGVCAERYSQEVFD PSGVASIACSSCVRAVDGKA VCGQCERALCGQCVRTCWGC GSVACTLCGLVDCSDMYEKV LCTSCAMFET |
| Tissue Specificity | Ubiquitous. Mostly expressed in thymus, testis, ovary, prostate, small intestine and spleen and less in colon. |
| Post Translational Modifications | Phosphorylated by ABL2/ARG in response to oxidative stress. |
| Function | Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. |
| Protein Name | Apoptosis Regulatory Protein SivaCd27-Binding ProteinCd27bp |
| Cellular Localisation | CytoplasmNucleusIn The NucleusAccumulates In Dot-Like Structures |
| Alternative Antibody Names | Anti-Apoptosis Regulatory Protein Siva antibodyAnti-Cd27-Binding Protein antibodyAnti-Cd27bp antibodyAnti-SIVA1 antibodyAnti-SIVA antibody |
Information sourced from Uniprot.org