• Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using QSK Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of LOVO cells using QSK Polyclonal Antibody

Anti-SIK3 antibody (490-570 Internal) (STJ95283)

SKU:
STJ95283

Current Stock:
Host: Rabbit
Applications: WB, IHC-P, IF-P, ELISA
Reactivity: Human, Mouse
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-Serine/Threonine-Protein Kinase Sik3 (490-570 Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SIK3
Gene ID: 23387
Uniprot ID: SIK3_HUMAN
Immunogen Region: 490-570 Internal
Specificity: SIK3 polyclonal antibody (Serine/Threonine-Protein Kinase Sik3) binds to endogenous Serine/Threonine-Protein Kinase Sik3 at the amino acid region 490-570 Internal.
Immunogen: The antiserum was produced against synthesized peptide derived from human QSK at amino acid range 521-570
Post Translational Modifications Phosphorylated at Thr-221 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-221 is inhibited in response to PTHLH/PTHrP. Phosphorylated at Thr-469 and Ser-551 in response to cAMP signaling (Probable).
Function Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus.
Protein Name Serine/Threonine-Protein Kinase Sik3
Salt-Inducible Kinase 3
Sik-3
Serine/Threonine-Protein Kinase Qsk
Cellular Localisation Cytoplasm
Locates To Punctate Structures Within The Cytoplasm On Binding To Ywhaz
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Sik3 antibody
Anti-Salt-Inducible Kinase 3 antibody
Anti-Sik-3 antibody
Anti-Serine/Threonine-Protein Kinase Qsk antibody
Anti-SIK3 antibody
Anti-KIAA0999 antibody
Anti-QSK antibody
Anti-L19 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance