||WB, IHC-P, IF-P, ELISA
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-Serine/Threonine-Protein Kinase Sik3 (490-570 Internal) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
||PBS, 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
||The antibody was affinity-purified from rabbit anti-serum by affinity-chromatography.
||WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000
||Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
||SIK3 polyclonal antibody (Serine/Threonine-Protein Kinase Sik3) binds to endogenous Serine/Threonine-Protein Kinase Sik3 at the amino acid region 490-570 Internal.
||The antiserum was produced against synthesized peptide derived from human QSK at amino acid range 521-570
| Post Translational Modifications || Phosphorylated at Thr-221 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-221 is inhibited in response to PTHLH/PTHrP. Phosphorylated at Thr-469 and Ser-551 in response to cAMP signaling (Probable). |
| Function || Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3 (Probable). Prevents HDAC4 translocation to the nucleus. |
| Protein Name || Serine/Threonine-Protein Kinase Sik3Salt-Inducible Kinase 3Sik-3Serine/Threonine-Protein Kinase Qsk |
| Cellular Localisation || CytoplasmLocates To Punctate Structures Within The Cytoplasm On Binding To Ywhaz |
| Alternative Antibody Names || Anti-Serine/Threonine-Protein Kinase Sik3 antibodyAnti-Salt-Inducible Kinase 3 antibodyAnti-Sik-3 antibodyAnti-Serine/Threonine-Protein Kinase Qsk antibodyAnti-SIK3 antibodyAnti-KIAA0999 antibodyAnti-QSK antibodyAnti-L19 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance