Anti-SHANK2 antibody (500-600) (STJ11100377)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SHANK2 (500-600) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SHANK2 |
| Gene ID | 22941 |
| Uniprot ID | SHAN2_HUMAN |
| Immunogen Region | 500-600 |
| Immunogen Sequence | PFALGANKDSLSAFEYPGPK RKLYSAVPGRLFVAVKPYQP QVDGEIPLHRGDRVKVLSIG EGGFWEGSARGHIGWFPAEC VEEVQCKPRDSQAETRADRS K |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SHANK2 (NP_036441.2). |
Additional Info
| Tissue Specificity | Isoform 3 is present in epithelial colonic cells (at protein level). |
| Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 2Shank2Cortactin-Binding Protein 1Cortbp1Proline-Rich Synapse-Associated Protein 1 |
| Database Links | Reactome: R-HSA-6794361 |
| Cellular Localisation | Apical Cell MembraneCytoplasmSynapsePostsynaptic DensityCell ProjectionGrowth ConeDendritic SpineColocalizes With Cortactin In Growth Cones In Differentiating Hippocampal NeuronsColocalized With Pde4d To The Apical Membrane Of Colonic Crypt Cells |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 2 antibodyAnti-Shank2 antibodyAnti-Cortactin-Binding Protein 1 antibodyAnti-Cortbp1 antibodyAnti-Proline-Rich Synapse-Associated Protein 1 antibodyAnti-SHANK2 antibodyAnti-CORTBP1 antibodyAnti-KIAA1022 antibodyAnti-PROSAP1 antibody |
Information sourced from Uniprot.org