• STJ70814 (0. 2µg/ml) staining of human lymph node lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • HEK293 overexpressing SH2D1A (RC204723) and probed with STJ70814 (mock transfection in first lane) , tested by Origene.

Anti-SH2D1A/SLAM associated protein antibody (Internal) (STJ70814)

SKU:
STJ70814-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB/IP
Reactivity: Human/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SH2D1A/SLAM associated protein (Internal) is suitable for use in ELISA, Western Blot and Immunoprecipitation research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SH2D1A
Gene ID: 4068
Uniprot ID: SH21A_HUMAN
Immunogen Region: Internal
Accession Number: NP_002342.1; NP_001108409.1
Immunogen Sequence: QYPVEKKSSARSTQ
Function Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Protein Name Sh2 Domain-Containing Protein 1a
Duncan Disease Sh2-Protein
Signaling Lymphocytic Activation Molecule-Associated Protein
Slam-Associated Protein
T-Cell Signal Transduction Molecule Sap
Database Links Reactome: R-HSA-198933
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Sh2 Domain-Containing Protein 1a antibody
Anti-Duncan Disease Sh2-Protein antibody
Anti-Signaling Lymphocytic Activation Molecule-Associated Protein antibody
Anti-Slam-Associated Protein antibody
Anti-T-Cell Signal Transduction Molecule Sap antibody
Anti-SH2D1A antibody
Anti-DSHP antibody
Anti-SAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance