| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SGIP1 |
| Gene ID: | 84251 |
| Uniprot ID: | SGIP1_HUMAN |
| Immunogen Region: | 357-631 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 357-631 of human SGIP1 (NP_001295132.1). |
| Immunogen Sequence: | MGAQDTLPVAAAFTETVNAY FKGADPSKCIVKITGEMVLS FPAGITRHFANNPSPAALTF RVINFSRLEHVLPNPQLLCC DNTQNDANTKEFWVNMPNLM THLKKVSEQKPQATYYNVDM LKYQVSAQGIQSTPLNLAVN WRCEPSSTDLRIDYKYNTDA MTTAVALNNVQFLVPIDGGV TKLQAVLPPAVWNAEQQRIL WKIPDISQKSENGGVGSLLA RFQLSEGPSKPSPLVVQFT |
| Tissue Specificity | Specifically expressed in brain. |
| Function | May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis. |
| Protein Name | Sh3-Containing Grb2-Like Protein 3-Interacting Protein 1Endophilin-3-Interacting Protein |
| Database Links | Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | MembraneClathrin-Coated PitPeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Sh3-Containing Grb2-Like Protein 3-Interacting Protein 1 antibodyAnti-Endophilin-3-Interacting Protein antibodyAnti-SGIP1 antibody |
Information sourced from Uniprot.org
