Anti-SFTPA1 antibody (122-221) (STJ25508)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SFTPA1 (122-221) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SFTPA1 |
| Gene ID | 653509 |
| Uniprot ID | SFTA1_HUMAN |
| Immunogen Region | 122-221 |
| Immunogen Sequence | RGALSLQGSIMTVGEKVFSS NGQSITFDAIQEACARAGGR IAVPRNPEENEAIASFVKKY NTYAYVGLTEGPSPGDFRYS DGTPVNYTNWYRGEPAGRGK |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 122-221 of human SFTPA1 (NP_005402.3). |
Additional Info
| Post Translational Modifications | N-acetylated. |
| Function | In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages. (Microbial infection) Recognition of M.tuberculosis by dendritic cells may occur partially via this molecule. Can recognize, bind, and opsonize pathogens to enhance their elimination by alveolar macrophages. (Microbial infection) Binds M.pneumoniae CARDS toxin, serves as one receptor for this pathogen. When SFTPA1 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen. |
| Protein Name | Pulmonary Surfactant-Associated Protein A1Psp-APspaSp-ASp-A135 Kda Pulmonary Surfactant-Associated ProteinAlveolar Proteinosis ProteinCollectin-4 |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-168179Reactome: R-HSA-391160Reactome: R-HSA-5683826Reactome: R-HSA-5686938Reactome: R-HSA-5688849Reactome: R-HSA-5688890 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSurface Film |
| Alternative Antibody Names | Anti-Pulmonary Surfactant-Associated Protein A1 antibodyAnti-Psp-A antibodyAnti-Pspa antibodyAnti-Sp-A antibodyAnti-Sp-A1 antibodyAnti-35 Kda Pulmonary Surfactant-Associated Protein antibodyAnti-Alveolar Proteinosis Protein antibodyAnti-Collectin-4 antibodyAnti-SFTPA1 antibodyAnti-COLEC4 antibodyAnti-PSAP antibodyAnti-SFTP1 antibodyAnti-SFTPA antibodyAnti-SFTPA1B antibody |
Information sourced from Uniprot.org