| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-SFRP1/FRP1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:2000.IHC: In paraffin embedded Human Uterus shows specific organellar stains in the epithelial cells of the endometrial gland. Recommended concentration, 4-6µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SFRP1 |
| Gene ID: |
6422 |
| Uniprot ID: |
SFRP1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_003003.3 |
| Immunogen Sequence: |
PNATEASKPQGTT |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. |
| Protein Name | Secreted Frizzled-Related Protein 1Frp-1Sfrp-1Secreted Apoptosis-Related Protein 2Sarp-2 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470 |
| Cellular Localisation | SecretedCell Membrane Or Extracellular Matrix-AssociatedReleased By Heparin-Binding |
| Alternative Antibody Names | Anti-Secreted Frizzled-Related Protein 1 antibodyAnti-Frp-1 antibodyAnti-Sfrp-1 antibodyAnti-Secreted Apoptosis-Related Protein 2 antibodyAnti-Sarp-2 antibodyAnti-SFRP1 antibodyAnti-FRP antibodyAnti-FRP1 antibodyAnti-SARP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
