| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SESN3 |
| Gene ID: | 143686 |
| Uniprot ID: | SESN3_HUMAN |
| Immunogen Region: | 1-310 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2). |
| Immunogen Sequence: | MNRGGGSPSAAANYLLCTNC RKVLRKDKRIRVSQPLTRGP SAFIPEKEVVQANTVDERTN FLVEEYSTSGRLDNITQVMS LHTQYLESFLRSQFYMLRMD GPLPLPYRHYIAIMAAARHQ CSYLINMHVDEFLKTGGIAE WLNGLEYVPQRLKNLNEINK LLAHRPWLITKEHIQKLVKT GENNWSLPELVHAVVLLAHY HALASFVFGSGINPERDPEI SNGFRLISVNNFCVCDLAN |
| Tissue Specificity | Widely expressed. |
| Function | May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. |
| Protein Name | Sestrin-3 |
| Database Links | Reactome: R-HSA-5628897 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sestrin-3 antibodyAnti-SESN3 antibodyAnti-SEST3 antibody |
Information sourced from Uniprot.org