Anti-SERPINE1/PAI-1 nanobody [SAA1079] (STJN000104)

Anti-SERPINE1/PAI-1 nanobody [SAA1079] (STJN000104)

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STJN000104
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Plasminogen Activator Inhibitor 1 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1079
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: SERPINE1
Gene ID: 5054
Uniprot ID: PAI1_HUMAN
Post Translational Modifications Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.
Function Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis.
Protein Name Plasminogen Activator Inhibitor 1
Pai
Pai-1
Endothelial Plasminogen Activator Inhibitor
Serpin E1
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1368108
Reactome: R-HSA-2173796
Reactome: R-HSA-3000178
Reactome: R-HSA-75205
Cellular Localisation Secreted
Alternative Nanobody Names Anti-Plasminogen Activator Inhibitor 1 nanobody
Anti-Pai nanobody
Anti-Pai-1 nanobody
Anti-Endothelial Plasminogen Activator Inhibitor nanobody
Anti-Serpin E1 nanobody
Anti-SERPINE1 nanobody
Anti-PAI1 nanobody
Anti-PLANH1 nanobody

Information sourced from Uniprot.org

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