| Tissue Specificity | Plasma. Synthesized in the liver. Like the related alpha-1-antitrypsin, its concentration increases in the acute phase of inflammation or infection. Found in the amyloid plaques from the hippocampus of Alzheimer disease brains. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. |
| Protein Name | Alpha-1-AntichymotrypsinActCell Growth-Inhibiting Gene 24/25 ProteinSerpin A3 Cleaved Into - Alpha-1-Antichymotrypsin His-Pro-Less |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Alpha-1-Antichymotrypsin antibodyAnti-Act antibodyAnti-Cell Growth-Inhibiting Gene 24/25 Protein antibodyAnti-Serpin A3 Cleaved Into - Alpha-1-Antichymotrypsin His-Pro-Less antibodyAnti-SERPINA3 antibodyAnti-AACT antibodyAnti-GIG24 antibodyAnti-GIG25 antibody |
Information sourced from Uniprot.org
![Western blot analysis of lysates from wild type (WT) and SERPINA3 knockdown (KD) Hep G2 cells using [KD Validated] SERPINA3 Rabbit pAb (STJ11107100) at 1:1000 dilution incubated overnight at 4C. <br>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br>Lysates/proteins: 25 Mu g per lane. <br>Blocking buffer: 3% nonfat dry milk in TBST. <br>Detection: ECL Basic Kit (](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/186296/408037/STJ11107100_1__46493.1744894472.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SERPINA3 knockdown (KD) Hep G2 cells using [KD Validated] SERPINA3 Rabbit pAb (STJ11107100) at 1:1000 dilution incubated overnight at 4C. <br>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br>Lysates/proteins: 25 Mu g per lane. <br>Blocking buffer: 3% nonfat dry milk in TBST. <br>Detection: ECL Basic Kit (")
![Western blot analysis of lysates from wild type (WT) and SERPINA3 knockdown (KD) Hep G2 cells using [KD Validated] SERPINA3 Rabbit pAb (STJ11107100) at 1:1000 dilution incubated overnight at 4C. <br>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br>Lysates/proteins: 25 Mu g per lane. <br>Blocking buffer: 3% nonfat dry milk in TBST. <br>Detection: ECL Basic Kit (](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/186296/408037/STJ11107100_1__46493.1744894472.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and SERPINA3 knockdown (KD) Hep G2 cells using [KD Validated] SERPINA3 Rabbit pAb (STJ11107100) at 1:1000 dilution incubated overnight at 4C. <br>Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. <br>Lysates/proteins: 25 Mu g per lane. <br>Blocking buffer: 3% nonfat dry milk in TBST. <br>Detection: ECL Basic Kit (")
